In vitro selective modulation of cellular glutathione by a humanized native milk protein isolate in normal cells and rat mammary carcinoma model

S Baruchel; G Viau

In vitro selective modulation of cellular glutathione by a humanized native milk protein isolate in normal cells and rat mammary carcinoma model

Anticancer Res. 1996 May-Jun;16(3A):1095-9.

Authors

S Baruchel¹, G Viau

Affiliation

¹ Department of Pediatrics and Oncology, McGill University, Montreal, Quebec, Canada.

PMID: 8702219

Abstract

We report the in vitro selective inhibitory activity of a humanized whey protein concentrate IMMUNOCAL on growth of mammary carcinoma cells and Jurkat T cells in comparison to normal peripheral blood mononuclear cells. We relate this inhibitory activity to a selective depletion of intracellular glutathione synthesis. The use of humanized whey protein concentrate as a food supplementation may have direct implication in clinical trial with adjuvant chemotherapy.

Publication types

Comparative Study

MeSH terms

Animals
Cell Division / drug effects
Cell Division / physiology
Female
Glutathione / biosynthesis*
Glutathione / blood
Humans
Leukocytes, Mononuclear / drug effects*
Leukocytes, Mononuclear / metabolism*
Mammary Neoplasms, Experimental / metabolism*
Milk Proteins / pharmacology*
Rats
Rats, Inbred F344
Reference Values
T-Lymphocytes / drug effects
T-Lymphocytes / metabolism
Tumor Cells, Cultured / drug effects
Whey Proteins

Substances

Milk Proteins
Whey Proteins
Glutathione